Orthopaedic PG Thesis Topics for MD/MS Students – 2025 Guide

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Choosing the right orthopaedic PG thesis topic is the first step toward a successful postgraduate career in MS or MD Orthopaedics. A strong research title reflects your clinical curiosity, analytical skills, and contribution to evidence-based orthopaedic practice. Below is a comprehensive list of 100 trending Orthopaedic Thesis Topics for postgraduate students, divided into 10 research domains such as trauma, arthroplasty, spine disorders, sports injuries, and more. At PubMedico, we guide medical students in finding innovative, feasible, and publication-ready orthopaedic thesis topics across diverse domains — from trauma and arthroscopy to spine and joint replacement.

 

Section 1: Trauma and Fracture Management

1. Comparative study of functional outcomes of proximal humerus fractures treated by PHILOS plate versus K-wire fixation.
2. Evaluation of clinical and radiological results of intertrochanteric femur fractures managed with PFN versus DHS.
3. Prospective analysis of distal tibial fractures treated with intramedullary nailing versus locking plate fixation.
4. Study of functional outcome in supracondylar fractures of humerus in children treated by closed reduction and percutaneous pinning.
5. Assessment of union and complication rate in tibial shaft fractures managed by reamed versus unreamed nailing.
6. Evaluation of MIPPO versus open plating techniques in distal femur fractures among adults.
7. Comparative study of primary versus delayed bone grafting in compound fractures of tibia.
8. Study of open versus closed reduction in management of ankle fractures: a functional outcome analysis.
9. Evaluation of role of early weight-bearing on healing of tibial fractures managed with interlocking nailing.
10. Prospective study on management of humeral shaft fractures with intramedullary interlocking nail versus dynamic compression plate.

Section 2: Arthroscopy and Sports Injuries

1. Comparative study of functional outcomes of ACL reconstruction using hamstring autograft versus bone-patellar tendon-bone graft.
2. Evaluation of meniscal repair versus partial meniscectomy on knee stability and long-term function.
3. Correlation between posterior tibial slope and incidence of anterior cruciate ligament injury in Indian athletes.
4. Prospective study of platelet-rich plasma injection versus conservative management in partial ACL tears.
5. Study of clinical outcome after arthroscopic debridement in early osteoarthritis of the knee.
6. Evaluation of return-to-sport rate after arthroscopic ACL reconstruction using single-bundle versus double-bundle technique.
7. Analysis of functional recovery after arthroscopic Bankart repair in recurrent shoulder dislocation.
8. Comparative study of arthroscopic versus open repair in rotator cuff tears in middle-aged adults.
9. Study of proprioceptive improvement following ACL reconstruction and rehabilitation training.
10. Prospective evaluation of clinical outcomes of lateral meniscus allograft transplantation in post-meniscectomy syndrome.

Section 3: Joint Replacement and Arthroplasty

1. Comparative study of cemented versus uncemented total hip arthroplasty in elderly osteoarthritis patients.
2. Evaluation of perioperative intravenous tranexamic acid in reducing blood loss during total knee arthroplasty.
3. Study of clinical and functional outcomes of posterior-stabilized versus cruciate-retaining total knee arthroplasty.
4. Correlation of BMI and postoperative outcomes following total knee replacement in Indian population.
5. Comparative analysis of computer-assisted navigation versus conventional technique in total knee arthroplasty.
6. Assessment of patient-reported outcome measures (PROMs) in total hip arthroplasty at one-year follow-up.
7. Study of postoperative complications in revision total hip arthroplasty: a prospective observational study.
8. Evaluation of functional outcome of dual-mobility cup in total hip arthroplasty among elderly patients.
9. Study on postoperative infection rates and antibiotic prophylaxis protocols in total joint replacements.
10. Analysis of the effect of early physiotherapy on functional recovery after total knee arthroplasty.

Section 4: Spine Disorders

1. 1. Comparative study of functional outcomes of posterior lumbar interbody fusion versus transforaminal lumbar interbody fusion in degenerative spondylolisthesis.
   2. Evaluation of radiological and clinical outcomes of short-segment versus long-segment fixation in thoracolumbar burst fractures.
   3. Study on the role of MRI-based Modic changes in predicting postoperative outcome in lumbar disc herniation.
   4. Correlation between sagittal balance parameters and functional outcomes in lumbar spine surgery.
   5. Prospective study of percutaneous pedicle screw fixation in unstable thoracolumbar fractures.
   6. Evaluation of minimally invasive decompression versus open laminectomy in single-level lumbar canal stenosis.
   7. Comparative analysis of posterior cervical fusion using lateral mass versus pedicle screw fixation.
   8. Study of neurological and functional recovery in spinal tuberculosis patients treated with combined surgical and medical management.
   9. Role of bone morphogenetic protein (BMP) in spinal fusion: a prospective randomized control study.
   10. Long-term outcome assessment of vertebroplasty versus kyphoplasty in osteoporotic vertebral compression fractures.

Section 5: Pediatric Orthopaedics

1. Evaluation of functional outcomes of Ponseti method in idiopathic congenital talipes equinovarus in children aged below two years.
2. Comparative study of open versus closed reduction in developmental dysplasia of the hip (DDH) between 6 months and 2 years of age.
3. Prospective analysis of elastic stable intramedullary nailing in pediatric femoral shaft fractures.
4. Study of functional outcome of supracondylar humerus fracture fixation using lateral-entry versus crossed K-wire configuration.
5. Evaluation of long-term outcomes in neglected clubfoot treated with posteromedial soft-tissue release.
6. Correlation between vitamin D deficiency and frequency of fractures in children: a hospital-based study.
7. Study on epidemiological profile and outcomes of slipped capital femoral epiphysis (SCFE) in adolescents.
8. Comparative evaluation of conservative versus surgical management in Blount’s disease.
9. Study on pattern and management outcomes of pediatric forearm fractures treated by titanium elastic nails.
10. Outcome analysis of guided growth procedures in angular deformities of the knee in children.

Section 6: Orthopaedic Oncology

1. Clinicopathological profile and outcome of patients with primary bone sarcomas: a tertiary care hospital study.
2. Evaluation of functional outcomes in limb-salvage surgery with endoprosthetic replacement for osteosarcoma of distal femur.
3. Study on the prognostic significance of serum alkaline phosphatase in osteosarcoma patients undergoing neoadjuvant chemotherapy.
4. Retrospective analysis of recurrence rates in giant cell tumor of bone managed with extended curettage versus wide excision.
5. Evaluation of quality of life in patients undergoing limb-salvage versus amputation in lower-limb malignancies.
6. Study on infection and mechanical complications following megaprosthesis reconstruction in bone tumors.
7. Immunohistochemical analysis of p53 expression in chondrosarcoma and its correlation with grade and prognosis.
8. Prospective study on functional outcome and survival rate after resection and reconstruction of pelvic tumors.
9. Evaluation of adjuvant bisphosphonate therapy in reducing recurrence in giant cell tumor of bone.
10. Study on epidemiology and clinical pattern of metastatic bone disease in tertiary cancer center patients.

Section 7: Bone Metabolism and Osteoporosis

1. 1. Correlation between bone mineral density and serum vitamin D levels in postmenopausal women.
   2. Study of the prevalence of osteoporosis among patients with chronic kidney disease using DEXA scanning.
   3. Evaluation of biochemical markers of bone turnover in postmenopausal osteoporosis.
   4. Comparative study of efficacy of bisphosphonates versus denosumab in treatment of senile osteoporosis.
   5. Study on relationship between sarcopenia and fracture risk among elderly population.
   6. Correlation between serum calcium, phosphate, and parathyroid hormone levels with BMD in osteopenic patients.
   7. Effect of physical activity on bone mineral density among middle-aged adults: a prospective study.
   8. Study on awareness and preventive practices regarding osteoporosis among perimenopausal women.
   9. Evaluation of role of vitamin D supplementation on fracture healing in osteoporotic patients.
   10. Comparative analysis of trabecular bone score versus BMD in predicting fragility fractures.

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Section 8: Infection and Inflammatory Disorders

1. Study of microbiological profile and antibiotic sensitivity pattern in chronic osteomyelitis.
2. Evaluation of functional outcome in surgical management of chronic osteomyelitis with antibiotic-loaded cement spacers.
3. Prospective study of outcome of Ilizarov technique in infected nonunion of long bones.
4. Study on clinical spectrum and management outcomes in tubercular arthritis of hip and knee joints.
5. Evaluation of local versus systemic antibiotic delivery in management of open fractures.
6. Study on clinical outcomes in septic arthritis of the knee treated with arthroscopic versus open debridement.
7. Correlation between serum CRP, ESR, and IL-6 levels with severity of prosthetic joint infections.
8. Role of negative pressure wound therapy in management of chronic orthopaedic infections.
9. Comparative study of limb salvage versus amputation in advanced osteomyelitis cases.
10. Study of post-operative infection rates following internal fixation surgeries and their risk factors.

Section 9: Hand and Microsurgery

1. Study on functional outcome of flexor tendon injuries repaired by modified Kessler technique followed by early mobilization.
2. Comparative evaluation of sensory recovery in digital nerve repair with versus without nerve conduit.
3. Study of functional results of vascularized bone graft in scaphoid nonunion.
4. Evaluation of outcomes of K-wire versus mini-plate fixation in metacarpal shaft fractures.
5. Prospective study of outcome of microsurgical free flaps in upper limb reconstruction.
6. Analysis of hand function in rheumatoid arthritis patients after synovectomy and tendon transfer.
7. Study on clinical outcome of volar plate fixation in distal radius intra-articular fractures.
8. Comparative evaluation of outcomes between conservative and surgical management in mallet finger injuries.
9. Study of epidemiology and outcomes of traumatic hand injuries in industrial workers.
10. Evaluation of sensory and motor recovery in peripheral nerve injuries managed with end-to-end repair versus grafting.

Section 10: Rehabilitation, Biomechanics, and Miscellaneous Topics

1. Assessment of gait and balance improvement following total knee replacement using computerized gait analysis.
2. Study on quality of life improvement after total hip arthroplasty using WOMAC and SF-36 scoring.
3. Evaluation of effectiveness of proprioceptive training in rehabilitation of post-ACL reconstruction patients.
4. Study on the role of aquatic physiotherapy in recovery of patients after total knee replacement.
5. Comparative study of functional outcomes of early versus delayed rehabilitation in distal radius fractures.
6. Analysis of occupational risk factors contributing to low back pain among healthcare workers.
7. Evaluation of ergonomic interventions in prevention of work-related musculoskeletal disorders among surgeons.
8. Study of correlation between BMI and knee joint loading using gait biomechanics.
9. Assessment of patient satisfaction and functional recovery following limb reconstruction surgeries.
10. Prospective analysis of psychological impact and rehabilitation outcomes in patients after major limb amputation.

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