Neurology PG Thesis Topics (MD/DNB) – Comprehensive Guide

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Choosing the right Neurology PG thesis topic is crucial for every MD or DNB postgraduate aiming to publish quality research in neurological sciences. This guide presents 50 updated and clinically feasible Neurology thesis topics (2024–2025), covering five major areas: Stroke, Cognitive Disorders, Epilepsy, Neuromuscular Diseases, and Neuroinfections.
These topics reflect current research trends in AIIMS, NIMHANS, PGIMER, and other tertiary centers across India.

Section 1: Cerebrovascular Disorders (Stroke and Vascular Neurology)

1. Study of clinical and radiological profile of ischemic stroke in young adults.
2. Correlation between serum homocysteine levels and severity of ischemic stroke.
3. Study of carotid intima-media thickness as a predictor of recurrent ischemic stroke.
4. Evaluation of serum uric acid as a prognostic marker in acute ischemic stroke.
5. Study of lipid profile abnormalities in ischemic versus hemorrhagic stroke patients.
6. Correlation between HbA1c levels and stroke severity in diabetic patients.
7. Study of post-stroke depression and its correlation with lesion location.
8. Evaluation of early neurological deterioration and predictors of poor outcome in acute stroke.
9. Comparative study of CT perfusion and MRI diffusion imaging in acute ischemic stroke.
10. Study on prevalence of carotid artery stenosis in patients with transient ischemic attacks.

Section 2: Neurodegenerative and Cognitive Disorders

1. Study on clinical and neuropsychological profile of patients with Alzheimer’s disease.
2. Correlation between vitamin D levels and cognitive impairment in elderly individuals.
3. Comparative study of cognitive decline in type 2 diabetic patients versus non-diabetics.
4. Evaluation of serum homocysteine and folate levels in patients with mild cognitive impairment.
5. Study of Parkinson’s disease patients: correlation of non-motor symptoms with disease severity.
6. Evaluation of autonomic dysfunction in Parkinson’s disease using heart rate variability.
7. Study on sleep disturbances and quality of life in patients with Parkinson’s disease.
8. Study on prevalence of depression and anxiety in dementia patients.
9. Correlation between MRI brain volumetry and cognitive function in Alzheimer’s disease.
10. Evaluation of plasma amyloid-beta and tau protein levels in cognitive impairment.

Section 3: Epilepsy and Seizure Disorders

1. Study of clinical profile and etiological spectrum of new-onset seizures in adults.
2. Correlation between serum prolactin levels and type of seizure in adults.
3. Study on psychiatric comorbidities in patients with temporal lobe epilepsy.
4. Evaluation of drug compliance and treatment outcomes in epilepsy patients.
5. Comparative study of EEG and MRI findings in localization-related epilepsy.
6. Study on serum sodium valproate levels and its correlation with seizure control.
7. Assessment of quality of life in patients with refractory epilepsy.
8. Study of metabolic abnormalities in patients presenting with status epilepticus.
9. Correlation of seizure frequency with serum magnesium and calcium levels.
10. Study of predictors of poor adherence to antiepileptic therapy among rural patients.

Section 4: Neuromuscular and Demyelinating Disorders

1. Clinical and electrophysiological study of Guillain-Barré syndrome and its variants.
2. Study of correlation between serum sodium levels and disability in Guillain-Barré syndrome.
3. Evaluation of serum anti-AQP4 antibodies in patients with neuromyelitis optica spectrum disorder.
4. Study on vitamin D deficiency and disease activity in multiple sclerosis.
5. Comparative study of MRI lesion load and disability scores in relapsing–remitting MS.
6. Evaluation of serum creatine kinase and lactate dehydrogenase in inflammatory myopathies.
7. Study on clinical and electrophysiological patterns in peripheral neuropathies of diabetes mellitus.
8. Correlation between nerve conduction velocity and duration of diabetes in distal symmetric polyneuropathy.
9. Study on effect of physiotherapy intervention in post-Guillain-Barré functional recovery.
10. Comparative study of acute inflammatory demyelinating polyneuropathy versus axonal variant of GBS.

Section 5: Neuroinfections, Headache, and Miscellaneous Disorders

1. Study on clinical and CSF profile of patients with tuberculous meningitis.
2. Evaluation of CSF adenosine deaminase levels as a diagnostic marker in meningitis.
3. Study of MRI brain findings in patients with viral encephalitis.
4. Correlation between serum procalcitonin and disease severity in bacterial meningitis.
5. Study on clinical profile and precipitating factors in patients with migraine.
6. Correlation between serum magnesium levels and frequency of migraine attacks.
7. Evaluation of sleep pattern disturbances in patients with chronic tension-type headache.
8. Study on neurocysticercosis: correlation between number of lesions and seizure recurrence.
9. Evaluation of cognitive and motor impairment in post-COVID-19 neurological syndrome.
10. Study on autonomic dysfunction in postural orthostatic tachycardia syndrome (POTS) using tilt-table testing.

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