Neurosurgery Thesis Topics Top 50 Research

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Looking for the best Neurosurgery research topic
This curated list by PubMedico includes 50 current, high-impact research ideas across all major neurosurgical subspecialties:
Neuro-Oncology, Cerebrovascular Surgery, Spine, Neurotrauma, and Functional Neurosurgery.
All topics align with recent trends from AIIMS, PGIMER, NIMHANS, CMC Vellore, JIPMER, and SCTIMST.

Section 1: Neuro-Oncology

1. Correlation between MGMT promoter methylation and overall survival in glioblastoma multiforme.
2. Comparative analysis of extent-of-resection and functional outcome in low-grade versus high-grade gliomas.
3. Evaluation of diffusion tensor imaging (DTI) tractography in pre-operative planning for eloquent-area tumors.
4. Study of Ki-67 proliferation index as a prognostic marker in meningiomas.
5. Correlation of peritumoral edema with histopathological grade in intracranial gliomas.
6. Outcome analysis of awake craniotomy versus general anaesthesia for tumors near motor cortex.
7. Assessment of post-operative cognitive changes in patients undergoing frontal lobe tumor resection.
8. Study on intra-operative ultrasound guidance in resection of intracerebral tumors.
9. Comparative study of endoscopic versus microscopic trans-sphenoidal pituitary tumor surgery.
10. Evaluation of complication rates and recurrence following resection of posterior-fossa meningiomas.

Section 2: Cerebrovascular & Skull-Base Surgery

1. Study on clinical outcome of aneurysm clipping versus coiling in anterior communicating artery aneurysms.
2. Evaluation of endovascular versus surgical management in middle cerebral artery aneurysms.
3. Correlation of Hunt–Hess and Fisher grades with outcome in aneurysmal subarachnoid hemorrhage.
4. Study on bypass graft patency and neurological outcome in moyamoya disease.
5. Assessment of risk factors for rebleeding in spontaneous intracerebral hemorrhage.
6. Study of radiological predictors of vasospasm following aneurysmal SAH.
7. Evaluation of decompressive craniectomy in malignant middle cerebral artery infarction.
8. Comparative study of outcomes in anterior versus posterior circulation aneurysms.
9. Analysis of surgical complications in cavernous malformation excision.
10. Study of skull-base reconstruction techniques and postoperative CSF-leak rates.

Section 3: Spine & Spinal Cord Surgery

1. Comparative study of anterior versus posterior approach in cervical spondylotic myelopathy.
2. Study of outcome and complications in lumbar canal stenosis treated by laminectomy versus laminoplasty.
3. Evaluation of minimally invasive versus open transforaminal lumbar interbody fusion (TLIF).
4. Correlation between sagittal alignment and postoperative outcome in degenerative scoliosis.
5. Study on neurological recovery following decompression in dorsal spinal tuberculosis.
6. Assessment of bone fusion rates using autograft versus synthetic substitutes in spinal fusion surgery.
7. Evaluation of intra-operative neuromonitoring in preventing neurological deficits in spinal surgery.
8. Study on clinical outcome of vertebroplasty versus kyphoplasty in osteoporotic compression fractures.
9. Correlation of MRI grading of disc herniation with surgical outcome in lumbar disc disease.
10. Comparative study of cervical disc arthroplasty versus anterior cervical discectomy and fusion.

Section 4: Neurotrauma & Critical-Care Neurosurgery

1. Correlation between serum S100-β protein levels and outcome in severe traumatic brain injury (TBI).
2. Study of prognostic value of Marshall CT classification in head-injury patients.
3. Comparative evaluation of decompressive craniectomy versus medical management in diffuse brain swelling.
4. Study on predictors of mortality in severe head injury using Rotterdam CT scoring.
5. Analysis of intracranial pressure trends and outcomes in TBI patients under ICP monitoring.
6. Correlation between initial GCS score and long-term neurological outcome in TBI.
7. Study on early versus delayed surgical evacuation of acute subdural hematoma.
8. Evaluation of CT perfusion imaging in prognosis of severe head injury.
9. Study of incidence and predictors of post-traumatic seizures following head injury.
10. Evaluation of outcomes in patients undergoing minimally invasive evacuation of intracerebral hematomas.

Section 5: Functional, Pediatric & Peripheral Nerve Neurosurgery

1. Study of outcomes of endoscopic third ventriculostomy (ETV) in pediatric hydrocephalus.
2. Correlation between endoscopic and microscopic approaches in pediatric posterior-fossa tumor surgery.
3. Evaluation of success rate and complications of ventriculoperitoneal shunt revisions.
4. Study of seizure control outcome in patients undergoing anterior temporal lobectomy for refractory epilepsy.
5. Assessment of outcome in microvascular decompression for trigeminal neuralgia.
6. Study on role of intra-operative neuro-navigation in functional neurosurgical procedures.
7. Comparative evaluation of peripheral nerve grafting versus nerve transfer in brachial-plexus injuries.
8. Study on surgical outcome of tethered-cord syndrome in children.
9. Evaluation of functional outcome after deep-brain stimulation in Parkinson’s disease.
10. Correlation of intra-operative neurophysiological monitoring with postoperative deficits in epilepsy surgery.

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