General Medicine PG Thesis Topics for MD/DNB Students – 2025 Comprehensive Guide

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Selecting a focused and feasible MD/DNB General Medicine thesis topic is the foundation of successful postgraduate research.
This 2025 guide compiles 100 trending Medicine research topics across ten clinical domains—ranging from
cardiology and pulmonology to neurology and geriatrics—based on the latest research trends from
AIIMS, PGIMER, JIPMER and NBE-approved institutes.
Each topic is original, practical, and publication-ready for Indian tertiary-care settings.

Section 1: Cardiology

1. Correlation of NT-proBNP levels with left-ventricular dysfunction in patients with heart failure.
2. Study on the clinical and angiographic profile of young patients presenting with acute myocardial infarction.
3. Evaluation of QTc prolongation in type 2 diabetes mellitus and its correlation with glycemic control.
4. Assessment of carotid intima-media thickness as an early marker of atherosclerosis in hypertensive patients.
5. Comparative study of echocardiographic diastolic dysfunction in obese versus non-obese individuals.
6. Evaluation of serum homocysteine levels in patients with coronary artery disease.
7. Study of prevalence of subclinical hypothyroidism in patients with heart failure with preserved ejection fraction.
8. Comparative study of 2D echocardiography and cardiac MRI in diagnosis of cardiomyopathy.
9. Study of microalbuminuria as a marker of cardiovascular risk in essential hypertension.
10. Evaluation of heart-rate variability in chronic smokers and its correlation with autonomic dysfunction.

Section 2: Pulmonology

1. Study on correlation between serum CRP levels and severity of acute exacerbations of COPD.
2. Evaluation of clinical profile and predictors of outcome in patients with community-acquired pneumonia.
3. Correlation of HbA1c levels with severity and recurrence of pulmonary tuberculosis.
4. Comparative study of spirometric patterns among diabetics and non-diabetics with COPD.
5. Assessment of sleep quality and oxygen desaturation index in patients with obstructive sleep apnea.
6. Study on prevalence of pulmonary hypertension in chronic lung disease using echocardiography.
7. Comparative evaluation of HRCT findings and spirometry in diagnosis of interstitial lung disease.
8. Correlation of serum uric acid with hypoxemia severity in COPD exacerbation.
9. Study of occupational exposure and lung function impairment in industrial workers.
10. Comparative study of six-minute walk distance in COPD patients before and after pulmonary rehabilitation.

Section 3: Nephrology

1. Study of serum uric-acid to creatinine ratio as a predictor of chronic kidney disease progression.
2. Comparative study of estimated GFR using MDRD versus CKD-EPI equations in diabetic nephropathy.
3. Correlation of microalbuminuria with carotid intima-media thickness in hypertensive patients.
4. Study of biochemical and hematological changes in patients undergoing hemodialysis.
5. Evaluation of anemia and iron profile in chronic kidney disease stages 3–5.
6. Study of electrolyte abnormalities in patients with acute kidney injury.
7. Correlation between serum uric acid and blood-pressure control in hypertensive CKD patients.
8. Assessment of bone mineral parameters in CKD and their association with disease stage.
9. Study of quality of life in CKD patients on hemodialysis using KDQOL-36 tool.
10. Evaluation of cardiovascular risk factors in CKD patients compared with healthy controls.

Section 4: Gastroenterology and Hepatology

1. Correlation between serum uric-acid to creatinine ratio and severity of non-alcoholic fatty liver disease (NAFLD).
2. Study of prevalence and biochemical profile of metabolic syndrome in chronic liver disease.
3. Comparative study of FibroScan and liver biopsy in grading hepatic fibrosis in hepatitis B patients.
4. Study of serum ferritin as a marker of disease severity in non-alcoholic steatohepatitis.
5. Evaluation of serum bilirubin and INR as predictors of mortality in acute-on-chronic liver failure.
6. Study on prevalence of Helicobacter pylori infection in dyspeptic patients and its correlation with gastritis severity.
7. Comparative study of upper GI endoscopy findings in chronic NSAID users versus non-users.
8. Correlation of C-reactive protein with activity index in inflammatory bowel disease.
9. Study on serum zinc and vitamin D status in patients with chronic liver disease.
10. Comparative analysis of outcome and complications in patients with acute pancreatitis based on BISAP score.

Section 5: Endocrinology and Metabolism

1. Correlation between HbA1c and pulmonary function tests in patients with type 2 diabetes mellitus.
2. Study of vitamin D, B12 and folate levels in newly diagnosed diabetic patients.
3. Comparative analysis of lipid profile and insulin resistance among obese versus non-obese adults.
4. Study of thyroid dysfunction in patients with metabolic syndrome.
5. Correlation between uric acid levels and glycemic control in patients with type 2 diabetes mellitus.
6. Evaluation of microalbuminuria as an early marker of diabetic nephropathy.
7. Study of prevalence of subclinical hypothyroidism in polycystic ovary syndrome.
8. Correlation of fasting insulin and HOMA-IR with anthropometric parameters in prediabetes.
9. Study of relationship between glycemic variability and QTc interval prolongation.
10. Comparative study of anthropometric indices as predictors of metabolic syndrome in adults.

Section 6: Rheumatology and Autoimmune Disorders

1. Study of clinical and biochemical profile of patients with rheumatoid arthritis and its correlation with disease activity score (DAS-28).
2. Evaluation of vitamin D levels and their association with disease activity in systemic lupus erythematosus (SLE).
3. Study on thyroid dysfunction in patients with rheumatoid arthritis and its correlation with disease severity.
4. Correlation between serum uric acid levels and inflammatory markers in gouty arthritis.
5. Comparative analysis of ANA and anti-dsDNA titers with disease activity in lupus nephritis.
6. Evaluation of cardiovascular risk in rheumatoid arthritis patients using carotid intima-media thickness.
7. Study on prevalence of metabolic syndrome in patients with ankylosing spondylitis.
8. Correlation between serum ferritin and disease activity in adult-onset Still’s disease.
9. Study of pulmonary function abnormalities in connective tissue disorders.
10. Comparative study of musculoskeletal ultrasound and clinical findings in early rheumatoid arthritis.

Section 7: Hematology

1. Study of iron deficiency anemia and its association with thyroid function abnormalities.
2. Evaluation of vitamin B12 and folate status in patients with megaloblastic anemia.
3. Comparative study of red-cell-distribution width (RDW) as a marker of anemia severity across etiologies.
4. Study of coagulation profile in chronic liver disease patients and its prognostic significance.
5. Correlation between ferritin levels and inflammatory markers in anemia of chronic disease.
6. Evaluation of hematological abnormalities in HIV-positive patients on antiretroviral therapy.
7. Study of bone-marrow findings in pancytopenia and their etiological correlation.
8. Assessment of nutritional anemia among women of reproductive age group in tertiary-care hospitals.
9. Study of thrombocytopenia in malaria and dengue: clinical and hematological comparison.
10. Correlation of serum hepcidin levels with anemia in chronic kidney disease.

Section 8: Neurology

1. Correlation between serum homocysteine and carotid intima-media thickness in ischemic-stroke patients.
2. Study of serum uric acid levels and their prognostic significance in acute ischemic stroke.
3. Comparative analysis of MRI-brain findings and glycemic variability in diabetic patients with neuropathy.
4. Evaluation of serum vitamin D levels in patients with migraine and their relationship with frequency and severity.
5. Study on cognitive impairment in hypertensive patients using Mini-Mental State Examination (MMSE).
6. Correlation between HbA1c levels and nerve-conduction velocity in type 2 diabetic neuropathy.
7. Study on clinical profile and etiological spectrum of seizures in adults in tertiary-care hospitals.
8. Evaluation of autonomic dysfunction in Parkinson’s disease using heart-rate variability.
9. Study of thyroid profile in patients presenting with acute ischemic stroke.
10. Comparative study of post-stroke depression and anxiety among ischemic and hemorrhagic-stroke survivors.

Section 9: Infectious Diseases

1. Study on clinical profile and predictors of severity in patients with dengue fever.
2. Evaluation of C-reactive protein and procalcitonin levels in differentiating bacterial from viral infections.
3. Study on correlation between CD4 count and opportunistic infections in HIV-positive patients.
4. Comparative study of clinical profile and outcomes of scrub typhus and leptospirosis.
5. Evaluation of hepatic dysfunction in patients with malaria and dengue coinfection.
6. Study of clinical and laboratory predictors of mortality in sepsis using SOFA score.
7. Study on antimicrobial-resistance pattern in patients with urinary-tract infection.
8. Comparative evaluation of Widal test and Typhidot in diagnosis of enteric fever.
9. Study of electrolyte abnormalities in patients with acute gastroenteritis.
10. Clinical and hematological profile of patients with post-COVID-19 inflammatory syndrome.

Section 10: Geriatric and General Medicine

1. Study on prevalence of frailty and its association with nutritional status in elderly outpatients.
2. Correlation between sarcopenia and vitamin D levels among elderly individuals.
3. Study on polypharmacy and its impact on quality of life among geriatric patients.
4. Evaluation of cognitive function and depression in elderly diabetics versus non-diabetics.
5. Study of comorbidities and medication adherence among elderly hypertensive patients.
6. Correlation between BMI, metabolic syndrome, and functional capacity in aging adults.
7. Study of electrolyte imbalance and its predictors in hospitalized elderly patients.
8. Comparative study of risk factors and mortality in community-acquired versus hospital-acquired pneumonia in elderly.
9. Study on prevalence of orthostatic hypotension and its correlation with antihypertensive therapy.
10. Evaluation of anemia and nutritional deficiencies in elderly patients attending medicine OPD.