Hematology Thesis Topics Top 50 Research

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Looking for the best Hematology research topic?
This curated list by PubMedico includes 50 current, high-impact research ideas across all major hematology subspecialties:
Hemato-Oncology, Coagulation Disorders, Anemias & Red Cell Disorders, Transfusion Medicine, and Diagnostic Hematology.
All topics align with recent trends from AIIMS, PGIMER, CMC Vellore, JIPMER, and SGPGIMS.

Section 1: Hemato-Oncology & Malignancies

1. Clinical Profile and Prognostic Markers in Acute Myeloid Leukemia: A Hospital-Based Study
2. Comparison of Treatment Outcomes in Acute Lymphoblastic Leukemia: Pediatric vs Adult Protocols
3. Role of Minimal Residual Disease Detection by Flow Cytometry in Predicting Relapse in Acute Leukemia
4. Clinical and Hematological Profile of Chronic Myeloid Leukemia Patients on Tyrosine Kinase Inhibitors
5. Hodgkin Lymphoma: Analysis of Clinical Staging, Treatment Response, and Survival Outcomes
6. Non-Hodgkin Lymphoma: Correlation Between Immunohistochemistry Subtypes and Clinical Outcomes
7. Multiple Myeloma: Evaluation of Revised International Staging System (R-ISS) in Predicting Treatment Outcomes
8. Myelodysplastic Syndrome: Clinical Features, IPSS-R Scoring, and Progression to Acute Leukemia
9. Primary Myelofibrosis: Clinical Presentation and Role of JAK2 Mutation Status in Disease Progression
10. Polycythemia Vera: Diagnostic Challenges and Management Outcomes in a Tertiary Care Center

Section 2: Coagulation & Thrombotic Disorders

1. Clinical Spectrum and Laboratory Profile of Hemophilia A: A Five-Year Hospital Study
2. Von Willebrand Disease: Correlation Between VWF Levels, Bleeding Score, and Clinical Manifestations
3. Immune Thrombocytopenic Purpura: Evaluation of First-Line Treatment Responses and Predictors of Chronicity
4. Thrombotic Thrombocytopenic Purpura: Clinical Features, ADAMTS13 Activity, and Therapeutic Outcomes
5. Deep Vein Thrombosis: Risk Factors, D-Dimer Utility, and Outcomes with Anticoagulation Therapy
6. Antiphospholipid Syndrome: Clinical Manifestations and Laboratory Correlation in Thrombotic Events
7. Disseminated Intravascular Coagulation: Etiology, ISTH Scoring, and Clinical Outcomes in ICU Patients
8. Hereditary Thrombophilia: Prevalence of Factor V Leiden and Prothrombin Gene Mutations in Thrombosis Patients
9. Heparin-Induced Thrombocytopenia: Incidence, 4T Score Application, and Management in Hospitalized Patients
10. Warfarin Therapy Monitoring: INR Control Quality and Bleeding Complications in Atrial Fibrillation Patients

Section 3: Anemias & Red Cell Disorders

1. Iron Deficiency Anemia: Etiology, Hematological Indices, and Response to Oral vs Intravenous Iron
2. Megaloblastic Anemia: Clinical Profile and Correlation Between Vitamin B12, Folate Levels, and Neurological Manifestations
3. Beta Thalassemia Major: Transfusion Requirements, Iron Overload, and Chelation Therapy Outcomes
4. Sickle Cell Disease: Clinical Complications, Hydroxyurea Therapy Response, and Quality of Life Assessment
5. Autoimmune Hemolytic Anemia: Classification, Direct Antiglobulin Test Patterns, and Treatment Outcomes
6. Glucose-6-Phosphate Dehydrogenase Deficiency: Prevalence, Triggering Factors, and Hemolytic Episodes
7. Aplastic Anemia: Etiology, Severity Grading, and Outcomes with Immunosuppressive Therapy
8. Paroxysmal Nocturnal Hemoglobinuria: Clinical Features, Flow Cytometry Findings, and Eculizumab Therapy
9. Hereditary Spherocytosis: Diagnostic Approach Using Osmotic Fragility and EMA Binding Test
10. Anemia of Chronic Disease: Hepcidin Levels, Iron Parameters, and Differentiation from Iron Deficiency Anemia

Section 4: Transfusion Medicine & Blood Banking

1. Blood Donor Demographics and Prevalence of Transfusion-Transmissible Infections: A Five-Year Analysis
2. ABO and Rh Blood Group Distribution Patterns and Their Clinical Significance in Transfusion Medicine
3. Hemolytic Transfusion Reactions: Incidence, Causes, and Laboratory Investigation Outcomes
4. Platelet Transfusion Practices: Indications, Platelet Increment Response, and Refractoriness
5. Massive Transfusion Protocol in Trauma Patients: Outcomes and Complications
6. Hemolytic Disease of the Newborn: Maternal Alloimmunization, Severity Assessment, and Exchange Transfusion
7. Therapeutic Apheresis: Indications, Procedures, and Clinical Outcomes in Various Hematological Disorders
8. Cold Chain Maintenance and Blood Component Quality: Storage Lesion Assessment
9. Voluntary vs Replacement Blood Donation: Comparative Analysis of Safety and Donor Retention
10. Transfusion-Associated Circulatory Overload (TACO): Risk Factors, Recognition, and Prevention Strategies

Section 5: Diagnostic Hematology & Laboratory Methods

1. Flow Cytometry in Leukemia Diagnosis: Comparative Analysis with Morphology and Immunohistochemistry
2. Bone Marrow Aspiration and Biopsy: Correlation Between Cytological and Histopathological Findings
3. Automated Hematology Analyzers: Flagging Efficiency and Peripheral Smear Correlation Study
4. Cytogenetic Analysis in Hematological Malignancies: Karyotyping vs FISH in Diagnostic Yield
5. Next-Generation Sequencing in Myeloid Malignancies: Mutation Profiling and Prognostic Implications
6. Peripheral Blood Film Morphology: Diagnostic Accuracy in Hematological Disorders by Different Observer Levels
7. Reticulocyte Count and Immature Reticulocyte Fraction: Utility in Diagnosing Bone Marrow Response
8. Quality Control in Hematology Laboratory: Internal and External Quality Assessment Program Analysis
9. Point-of-Care Testing in Hematology: Hemoglobin Estimation Accuracy Compared to Laboratory Methods
10. Liquid Biopsy in Hematological Malignancies: Cell-Free DNA Analysis for Disease Monitoring

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