MD Pathology Thesis Topics Top 100 Research

Histopathology, Cytopathology & Molecular Diagnostics 2026

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Looking for cutting-edge MD Pathology research topics?
This comprehensive list by PubMedico includes 100 advanced, high-impact research ideas across all major pathology subspecialties:
Histopathology & Surgical Pathology, Cytopathology & FNAC, Hematopathology & Flow Cytometry, Molecular Pathology & Genomics, Clinical Pathology & Laboratory Medicine, Immunohistochemistry & Biomarkers, Digital Pathology & Artificial Intelligence, Transfusion Medicine & Blood Banking, Forensic Pathology & Autopsy, and Quality Assurance & Laboratory Management.
All topics align with latest 2026 trends from AIIMS, PGIMER, JIPMER, Tata Memorial Centre, and leading pathology departments worldwide.

Section 1: Histopathology & Surgical Pathology

1. Histomorphological Spectrum and Immunohistochemical Profile of Breast Carcinoma: A Tertiary Care Study
2. Comparative Analysis of Tumor Grade and Molecular Subtypes in Colorectal Adenocarcinoma
3. Evaluation of Tumor Microenvironment and PD-L1 Expression in Non-Small Cell Lung Cancer
4. Study on Histopathological Patterns and Helicobacter pylori Association in Gastric Lesions
5. Assessment of Endometrial Hyperplasia: WHO 2020 Classification and Cancer Risk
6. Comparative Study of Gleason Grading vs ISUP Grading in Prostate Adenocarcinoma
7. Evaluation of Liver Biopsy Findings in Non-Alcoholic Fatty Liver Disease: Fibrosis Staging
8. Study on Histological Heterogeneity in Renal Cell Carcinoma Subtypes
9. Assessment of Tumor Budding and Desmoplastic Reaction in Oral Squamous Cell Carcinoma
10. Evaluation of Mesothelioma vs Reactive Mesothelial Proliferation: Diagnostic Challenges

Section 2: Cytopathology & Fine Needle Aspiration Cytology

1. Evaluation of Thyroid Lesions Using Bethesda System: Cyto-Histopathological Correlation
2. Comparative Study of Liquid-Based Cytology vs Conventional PAP Smear in Cervical Cancer Screening
3. Assessment of p16 and Ki-67 Dual Staining in Liquid-Based Cervical Cytology
4. Study on FNAC of Lymph Node: Role in Diagnosing Tuberculous Lymphadenitis
5. Evaluation of Salivary Gland Lesions: FNAC and Milan System for Reporting
6. Comparative Analysis of FNAC vs Core Needle Biopsy in Breast Lesions
7. Assessment of Exfoliative Cytology in Oral Potentially Malignant Disorders
8. Study on Pleural and Peritoneal Fluid Cytology: Malignant vs Reactive Effusions
9. Evaluation of Urine Cytology in Detecting Urothelial Carcinoma: Paris System
10. Role of Cell Block Preparation in Enhancing Diagnostic Accuracy of FNAC

Section 3: Hematopathology & Flow Cytometry

1. Clinical and Hematological Profile of Acute Leukemia: Immunophenotyping Correlation
2. Evaluation of Bone Marrow Findings in Pancytopenia: Etiology and Outcomes
3. Study on Flow Cytometry in Diagnosing and Classifying Non-Hodgkin Lymphoma
4. Assessment of Minimal Residual Disease in Acute Lymphoblastic Leukemia Using Flow Cytometry
5. Comparative Analysis of Morphology vs Immunophenotyping in Myelodysplastic Syndrome
6. Evaluation of Plasma Cell Dyscrasias: Immunofixation and Free Light Chain Assay
7. Study on Bone Marrow Biopsy Findings in Lymphoma Staging
8. Assessment of Hemophagocytic Lymphohistiocytosis: Diagnostic Criteria and Outcomes
9. Evaluation of Paroxysmal Nocturnal Hemoglobinuria Using Flow Cytometry
10. Study on Peripheral Blood Smear in Detecting Hematological Malignancies

Section 4: Molecular Pathology & Genomics

1. Detection of EGFR Mutations in Lung Adenocarcinoma: Impact on Targeted Therapy
2. Evaluation of BRAF V600E Mutation in Papillary Thyroid Carcinoma Using PCR
3. Study on Microsatellite Instability Testing in Colorectal Cancer: IHC vs PCR
4. Assessment of HER2 Gene Amplification in Gastric Cancer: FISH vs IHC
5. Comparative Study of BCR-ABL Fusion Gene Detection Methods in CML
6. Evaluation of Liquid Biopsy and Circulating Tumor DNA in Cancer Monitoring
7. Study on JAK2 V617F Mutation in Myeloproliferative Neoplasms
8. Assessment of Next-Generation Sequencing in Comprehensive Genomic Profiling
9. Evaluation of PML-RARA Fusion Gene in Acute Promyelocytic Leukemia
10. Study on HPV Genotyping in Cervical Cancer: Role in Risk Stratification

Section 5: Clinical Pathology & Laboratory Medicine

1. Evaluation of Serum Tumor Markers in Early Detection and Monitoring of Malignancies
2. Study on Vitamin D Deficiency and Its Clinical Correlations in Indian Population
3. Assessment of Thyroid Function Tests: Subclinical Hypothyroidism Prevalence
4. Comparative Study of HbA1c vs Fasting Blood Sugar in Diabetes Screening
5. Evaluation of Lipid Profile and Cardiovascular Risk Assessment
6. Study on D-Dimer Levels in Diagnosing Thromboembolic Disorders
7. Assessment of Serum Ferritin and Iron Studies in Anemia Classification
8. Evaluation of Procalcitonin vs CRP in Diagnosing Bacterial Sepsis
9. Study on Urine Routine and Microscopy in Urinary Tract Infections
10. Assessment of Serum Electrolytes and Acid-Base Disorders in ICU Patients

Section 6: Immunohistochemistry & Biomarkers

1. Evaluation of ER, PR, and HER2 Status in Breast Cancer: Prognostic Implications
2. Study on PD-L1 Expression in Various Tumors: Predictive Marker for Immunotherapy
3. Assessment of Ki-67 Proliferation Index in Neuroendocrine Tumors
4. Comparative Analysis of p53 and p16 Expression in Oral Squamous Cell Carcinoma
5. Evaluation of CD10, BCL6, and MUM1 in Diffuse Large B-Cell Lymphoma Subtyping
6. Study on Chromogranin and Synaptophysin in Neuroendocrine Differentiation
7. Assessment of ALK Immunohistochemistry in Lung Adenocarcinoma
8. Evaluation of Mismatch Repair Proteins in Lynch Syndrome Screening
9. Study on TTF-1 and Napsin A in Lung Adenocarcinoma Diagnosis
10. Assessment of GATA3 and Uroplakin in Urothelial Carcinoma

Section 7: Digital Pathology & Artificial Intelligence

1. Role of Whole Slide Imaging in Telepathology and Remote Diagnosis
2. Evaluation of AI-Assisted Detection of Tumor Cells in Histopathology Slides
3. Study on Deep Learning Algorithms in Predicting Breast Cancer Molecular Subtypes
4. Assessment of Digital Image Analysis in Quantifying Immunohistochemical Staining
5. Comparative Study of Manual vs AI-Based Mitotic Count in Tumors
6. Evaluation of Machine Learning in Detecting Lymph Node Metastasis
7. Study on Cloud-Based Digital Pathology Platforms for Multi-Institutional Research
8. Assessment of AI in Predicting Molecular Alterations from H&E Images
9. Role of Augmented Reality in Pathology Education and Training
10. Evaluation of Computational Pathology in Tumor Microenvironment Analysis

Section 8: Transfusion Medicine & Blood Banking

1. Study on Prevalence of ABO and Rh Blood Groups in Regional Population
2. Evaluation of Pre-Transfusion Testing: Cross-Match Protocols and Safety
3. Assessment of Blood Donor Screening for Transfusion-Transmissible Infections
4. Comparative Study of Direct Antiglobulin Test in Hemolytic Anemia
5. Evaluation of Platelet Transfusion Refractoriness: Causes and Management
6. Study on Component Therapy vs Whole Blood Transfusion in Trauma Patients
7. Assessment of Blood Storage Lesions and Their Clinical Impact
8. Evaluation of Hemolytic Disease of Newborn: Antibody Screening and Management
9. Study on Therapeutic Apheresis in Hematological Disorders
10. Assessment of Adverse Transfusion Reactions: Hemovigilance Data Analysis

Section 9: Forensic Pathology & Autopsy

1. Histopathological Examination of Organs in Sudden Cardiac Death: Autopsy Study
2. Evaluation of Asphyxial Deaths: Medico-Legal Autopsy Findings
3. Study on Pattern of Injuries in Road Traffic Accidents: Forensic Analysis
4. Assessment of Drowning vs Non-Drowning Deaths: Diatom Test Correlation
5. Evaluation of Poisoning Deaths: Toxicological and Histopathological Correlation
6. Study on Time Since Death Estimation Using Biochemical Markers
7. Assessment of Burn Deaths: Histopathological vs Circumstantial Evidence
8. Evaluation of Maternal Mortality: Autopsy-Based Causal Analysis
9. Study on Neonatal Autopsy: Congenital Anomalies and Birth Asphyxia
10. Assessment of Post-Mortem Interval Using Entomological Evidence

Section 10: Quality Assurance & Laboratory Management

1. Implementation of Six Sigma Methodology in Clinical Laboratory: Quality Metrics
2. Evaluation of Internal Quality Control and External Quality Assessment Programs
3. Study on Pre-Analytical Errors in Clinical Laboratory: Root Cause Analysis
4. Assessment of Turnaround Time in Pathology Reporting: Quality Improvement Project
5. Evaluation of NABL Accreditation Impact on Laboratory Performance
6. Study on Specimen Rejection Rates and Corrective Actions
7. Assessment of Laboratory Information System in Workflow Optimization
8. Evaluation of Cost-Effectiveness Analysis of Laboratory Test Utilization
9. Study on Critical Value Notification: Compliance and Patient Safety
10. Assessment of Biosafety Practices in Pathology Laboratory

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